Genetic Testing
Cancer is unfortunately a very common disease. 1 in 2 men and 1 in 3 women will develop cancer in their lifetime. Understanding whether the cancer is due to a hereditary cancer syndrome becomes important for understanding risk to develop future cancers and risks to other family members as well as for guiding surveillance and management.
Identifying Hereditary Cancer Syndromes
When a patient has cancer at a younger age, bilateral or multifocal cancers, cancer that is less common for their gender (ex. Breast cancer in men), histology associated with a higher risk for a genetic condition (ex. Triple negative breast cancer), or a family history of cancer a diagnosis of a hereditary cancer syndrome should be considered.
Our PanOnco Hereditary Cancer NGS Panels make diagnosis of a hereditary cancer syndrome simple so patients can get started with the best surveillance and management plan for decreasing their risk to develop cancer and identifying family members that may be at risk.
When should I think about PanOnco panel testing?
  • The patient’s personal and family history is suggestive of a variety of differential diagnoses.
  • The patient who has little information about their family history.
  • Patients with no personal history of cancer but a family history of cancer.
Our panels will allow you to check for multiple genes at once giving you efficiency, accuracy, and less expense than ordering several single gene tests in a row.
Our PanOnco tests for single familial cancer syndromes include sequencing and duplication / deletion analysis unless otherwise noted. These tests are a more cost effective way to test for a specific hereditary cancer syndrome when you have a high suspicion for a specific diagnosis based on the patient’s personal and family history.
You have the option of testing for a known familial mutation (when one is known), testing for a mutation in a specific gene (ex. Testing for a mutation in MSH6 due to absent immunohistochemistry staining of the MSH6 protein) or testing for each of the genes known to be associated with the particular syndrome (ex. Testing for all 4 mismatch repair genes when you suspect Lynch syndrome).
When should I think about PanOnco single familial cancer syndrome testing?
  • When there is a high suspicion for a specific hereditary cancer syndrome.
  • When the patient has a family member with a known mutation.
  • When histological findings are suggestive of a mutation in a particular gene.